一、团队简介

主要从事绿色有机合成化学的研究，即发展新催化体系、新方法为天然活性化合物及其类似物（具有药物核心骨架）的多样性合成提供绿色、全新的合成方法。

二、成员简介

汪煦，1990年生，博士，副研究员，硕士研究生导师，3522vip浦京集团官网“3331高层次人才计划”优秀青年学者。2018年毕业于华南理工大学，有机化学专业，获得博士学位。近年来主持和参与各级科研项目10余项，包括主持博士后面上项目1项，主持广西自然科学基金项目2项，主持广西高校中青年教师科研基础能力提升项目1项，主持广西研究生教育创新计划项目1项，主要参与国家自然科学基金项目2项等。发表科研论文20余篇，以第一作者或通讯作者发表SCI收录论文14篇，SCI二区以上论文12篇，已获授权发明专利4项。

1.研究方向

（1）金属催化合成药物分子；

（2）金属配合物的合成；

（3）化合物抗肿瘤、抗炎等药理活性研究。

2.科研项目及成果

  （1）Hui-Shu Lin, Yong-Zhou Pan, Yu-Hong Tian, Ying-Ming Pan*, Xu Wang*. Palladium-Catalyzed Tandem Cyclization of 2-(2 Ethynylphenyl)acetonitriles and Isocyanides: Access to Indeno[2,1-b]pyrroles. Adv. Synth. Catal., 2022, 364, 1117-1121.

  （2）Hui-Shu Lin, Jin-Ping Fu, Yu-Hong Tian, Wen-Yi Huang, Hao Cheng, Guang-Ming Liang*, Xu Wang*. Design, synthesis, crystal structure and DFT analysis of 1-(1,2,2-triphenylvinyl)-1H-indoles with aggregation-induced emission property. Journal of Molecular Structure, 2023, 1271, 134022.

  （3）Xu Wang*, Jin-Ping Fu, Jia-Hui Mo, Yu-Hong Tian, Chun-You Liu, Hai-Tao Tang, Zi-Jun Sun,* and Ying-Ming Pan*. Assembly of 5-Aminoimidazoles via Palladium-Catalysed Double Isocyanide Insertion Reaction . Adv. Synth. Catal., 2021, 363, 2762-2766.

  （4）Meng Wang, Zhikun Liu, Xiaochao Huang*, Yuanhang Chen, Yanming Wang, Jing Kong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang*, and Hengshan Wang*. Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells. Bioorg Chem., 2021, 110, 104741.

   （5）Xu Wang*, Jin-Ping Fu, Jia-Xing Xie, Qing-Hu Teng, Hai-Tao Tang, and Ying-Ming Pan*. Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion. Org. Biomol. Chem., 2020, 18, 4936-4940.

  （6）Xu Wang*, Fei Dong, Wen-Feng Hao, Xu-Kai Zhou, Kai-Yun Chen, Jin-Ping Fu*. Synthesis, Crystal Structures and Antioxidant Activities of 1, 5-Diketone Derivatives. Chinese J. Struct. Chem., 2020, 39, 1655-1661.

  （7）Zijun Sun*, Guisong Fang, Jinglin Li, Jiahuan Mo, Xiong He, Xu Wang*, Zhiqiang Yu*. Preparation of (Ti, Zr) co-doped hematite photoanode for enhanced photoelectrochemical water splitting. Chem Phy Lett., 2020, 754, 137736.

  （8）Xu Wang, Jiawei Li, Yubing Huang, Jiayi Zhu, Rongrong Hu, Wanqing Wu*, and Huanfeng Jiang*, Facile Synthesis of π-Conjugated Quinazoline-Substituted Ethenes from 2-Ethynylanilines and Benzonitriles under Transition-Metal-Free Conditions. J. Org. Chem., 2018, 83, 10453-10464.

  （9）Xu Wang, Dandan He, Yubing Huang, Qihang Fan, Wanqing Wu*, and Huanfeng Jiang*, Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen, J. Org. Chem., 2018. 83, 5458-5466.

 （10）Xu Wang, Wenfang Xiong, Yubing Huang, Jiayi Zhu, Qiong Hu, Wanqing Wu*, and Huanfeng Jiang*, Palladium-Catalyzed Synthesis of 1H-Indenes and Phthalimideones via Isocyanide Insertion. Org. Lett., 2017, 19, 5818-5821.

 （11）Xu Wang, Yubing Huang, Yanli Xu, Wanqing Wu,* and Huanfeng Jiang*, Palladium-Catalyzed Denitrogenative Synthesis of Aryl Ketones from Arylhydrazines and Nitriles Using O₂ as Sole Oxidant. J. Org. Chem., 2017, 82, 2211-2218. 

 （12） Xu Wang, Shen-yan Li, Ying-ming Pan,* Heng-shan Wang, Zhen-feng Chen,* and Ke-bin Huang, Regioselective Palladium-Catalyzed Decarboxylative Cross-Coupling Reaction of Alkenyl Acids with Coumarins: Synthesis of 3-Styrylcoumarin Compounds. J. Org. Chem., 2015, 80, 2407-2412.

 （13）Xu Wang, Shen-yan Li, Ying-ming Pan,* Heng-shan Wang, Hong Liang, Zhen-feng Chen,* and Xiao-huan Qin, Samarium(III)-Catalyzed C(sp3)-H Bond Activation: Synthesis of Indolizines via C-C and C-N Coupling between 2-Alkylazaarenes and Propargylic Alcohols. Org. Lett., 2014, 16, 580-583.

 （14）Xu Wang, Ying-ming Pan,* Xiao-chao Huang, Zhong-yuan Mao and Heng-shan Wang*, A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032.

刘泉, 男，博士，副教授

1.教育经历

(1) 2012-08 至 2014-09, 日本东北大学, 博士后

(2) 2005-09 至 2011-06, 南京大学, 化学, 博士

(3) 2001-09 至 2005-06, 南京大学, 化学, 学士

2.研究方向

（1）卟啉酞菁衍生物的合成和性质研究

（2）光电功能染料分子

3.科研项目及成果

(1) Quan Liu; Soji Shimizu; Nagao Kobayashi ; Cyclophanes Consisting of Bowl-Shaped Aromatics: Three Isomers of anti-[2.2](1,4)Subphthalocyaninophane., Angewandte Chemie International Edition, 2015, 54, 5187-5191.

(2) Quan Liu; Quan-You Feng; Hiroko Yamada; Zhong-Sheng Wang; Noboru Ono; Xiao-Zeng You; Zhen Shen; Tuning the spectroscopic, electrochemical and photovoltaic properties of triarylaminebased sensitizers through ring-fused thiophene bridge, Chemistry-An Asian Journal, 2012, 7, 1312-1319.

(3) Quan Liu; Fantai Kong; Tetsuo Okujima; Hiroko Yamada; Song-Yuan Dai; Hidemitsu Uno; Noboru Ono; Xiao-Zeng You; Zhen Shen ; Synthesis and spectroscopic properties of ring-fused thiophene bridged push-pull dyes and their application in dye-sensitized solar cells, Tetrahedron Letters, 2012, 53, 3264-326.

(4) Xingyu Qu; Quan Liu; Xiaoning Ji; Huachao Chen; Zhikuan Zhou; Zhen Shen ; Enhancing the stokes’ shift of BODIPY dyes via through bond energy transfer and its application for Fe3+- detection in live cell imaging, Chemical Communications, 2012, 2012: 4600-4602.

(5) 周晓彦; 吕树升; 刘泉; 沈珍 ; 一种新型检测铜离子和磷酸氢根阴离子的荧光逻辑门探针, 无机化学学报, 2012, 28, 1483-1488.